The Challenge

Treating diseases with Biologics currently requires Injection or Infusions. This causes several disadvantages.

Patient Safety Risks

Cost

Low Patient Compliance

Challenges with Bioavailability

Drug Class
Properties
Challenges
BCS Class III/IV
oral drugs

Low permeability Low solubility

Low systemic bioavailability

Variable plasma levels

Biopharmaceuticals

High molecular weight

High solubility

Enzymatic instability

Need for parenteral administration.

Low patient compliance and adherence to

therapy

Side effects, e.g., injection site reactions (ISRs)

How Does It Work?

KriyaBio’s drug delivery technology is based on our patent-pending drug permeation enhancer KB01. KB01 is a smart tight junction modulator that interacts with epithelial tight junctions in a reversible manner. KB01 safely enables the mucosal absorption of co-administered therapies.

BIOAVAILABILITY

NON INVASIVE

Adequate Safety

Mechanism of Action: reversible opening of Tight Junctions

Tight junctions closed
Tight junctions opened
Tight junctions closed: Completely reversible and safe mechanism

J. Brunner, et al., Impact of peptide permeation enhancer on tight junctions opening cellular mechanisms. Biochem. Pharmacol. (2022).

From Injection to Local Application


Oral delivery (systemic)

Increase oral bioavailability for difficult molecules (GLP1 analogues, BCS III APIs)

Transmucosal delivery (systemic)

Mucosal permeabilization for rapid systemic absorption of small molecules and peptides

Ocular delivery (e.g., AMD, DR, VD)

Transcorneal delivery of biologics avoiding tedious intravitreal injection

The Advantages

Broad range of therapeutic entities

High predictability and safety

Stand alone permeation approach

Adaptability towards formulation

Ease of manufacture

Classification of PEs

Classification of PEs

J. Brunner, S. Ragupathy, G. Borchard, Target-specific tight junction modulators. Adv. Drug Deliv. Rev. 171 (2021) 266-288. doi: 10.1016/j.addr.2021.02.008

GET IN TOUCH

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Contact us

KriyaBio SA

Grosspeteranlage 29

4051 Basel

info@kriyabio.com