The Challenge
Treating diseases with Biologics currently requires Injection or Infusions. This causes several disadvantages.

Patient Safety Risks

Cost

Low Patient Compliance
Challenges with Bioavailability
Drug Class
Properties
Challenges
BCS Class III/IV
oral drugs
Low permeability Low solubility
Low systemic bioavailability
Variable plasma levels
Biopharmaceuticals
High molecular weight
High solubility
Enzymatic instability
Need for parenteral administration.
Low patient compliance and adherence to
therapy
Side effects, e.g., injection site reactions (ISRs)
How Does It Work?
KriyaBio’s drug delivery technology is based on our patent-pending drug permeation enhancer KB01. KB01 is a smart tight junction modulator that interacts with epithelial tight junctions in a reversible manner. KB01 safely enables the mucosal absorption of co-administered therapies.

BIOAVAILABILITY

NON INVASIVE

Adequate Safety
Mechanism of Action: reversible opening of Tight Junctions



J. Brunner, et al., Impact of peptide permeation enhancer on tight junctions opening cellular mechanisms. Biochem. Pharmacol. (2022).
From Injection to Local Application

Oral delivery (systemic)
Increase oral bioavailability for difficult molecules (GLP1 analogues, BCS III APIs)

Transmucosal delivery (systemic)
Mucosal permeabilization for rapid systemic absorption of small molecules and peptides

Ocular delivery (e.g., AMD, DR, VD)
Transcorneal delivery of biologics avoiding tedious intravitreal injection
The Advantages

Broad range of therapeutic entities

High predictability and safety

Stand alone permeation approach

Adaptability towards formulation

Ease of manufacture
Classification of PEs

J. Brunner, S. Ragupathy, G. Borchard, Target-specific tight junction modulators. Adv. Drug Deliv. Rev. 171 (2021) 266-288. doi: 10.1016/j.addr.2021.02.008
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